| Country | City | Km (section) | Km (cuml.) | Connection |
| F | Dunkerque | 0 | 0 | |
| F | Lille | 71 | 71 | |
| B | Mons | 77 | 149 | E19 |
| B | Charleroi | 51 | 200 | E420 |
| B | Namur | 41 | 241 | E411 |
| B | Liège | 61 | 302 | E25, E40, E46, E313 |
| B | Sankt-Vith | 87 | 389 | E421 |
| D | Wittlich | 85 | 474 | |
| D | Bingen | 91 | 565 | E31 |
| D | Wiesbaden | 33 | 598 | |
| D | Frankfurt am Main | 41 | 639 | E35, E451 |
| D | Aschaffenburg | 41 | 680 | E41 |
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